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🌊 The Ocean Library · GP clinical topic

Preconception Advice

Reviewed and updated by practising UK GPs, overseen by our Clinical Advisory Officer.

🧭 When to offer pre-conception care

Pre-conception care is not a diagnosis but a proactive consultation, offered to anyone of reproductive age who:

• Is planning a pregnancy.

• Wishes to stop contraception.

• Has a long-term condition or medication that could affect pregnancy.

The aim is to optimise health before conception to improve outcomes for parent and baby.

Two facts make this consultation matter:

• First, the neural tube closes by around 28 days – often before a pregnancy is recognised – so folic acid and a medication review must happen before conception, not at booking.

• Second, around two-thirds of maternal deaths in the UK now occur in women with pre-existing medical conditions, so the people who benefit most are often those already under your care for chronic disease.

The two highest-value actions are simple: start folic acid, and review every medication for teratogenicity before contraception is stopped. Be proactive – raise pre-conception health opportunistically rather than waiting to be asked.

Especially important to offer to

• Anyone with a chronic condition or its medication affecting pregnancy – diabetes, epilepsy, hypertension, thyroid, asthma, cardiac, renal or autoimmune disease

• Anyone taking a known teratogen – sodium valproate, isotretinoin, methotrexate, ACE inhibitors/ARBs, warfarin or lithium

• A previous adverse pregnancy outcome – neural tube defect (NTD) or congenital anomaly, recurrent miscarriage, stillbirth, pre-eclampsia or gestational diabetes

• Smokers, high alcohol or recreational drug use, and a raised or low body mass index (BMI)

• Family origin or family history suggesting a haemoglobinopathy or inheritable condition

Opportunities to raise it

• Requests to stop contraception, and routine contraception reviews

• Chronic disease and medication reviews

• Sexual health and cervical screening attendance

• After a miscarriage, ectopic or termination

• Any consultation where a wish to conceive is mentioned

Source: NICE NG247 · NICE NG3


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