π§ When to suspect
Endometriosis is the growth of endometrial-like tissue outside the uterus, most often on the pelvic peritoneum, ovaries and uterosacral ligaments.
β’ Ovarian deposits form endometriomas, the "chocolate cyst".
β’ Endometriosis is a chronic, oestrogen-dependent inflammatory condition.
β’ It affects roughly 1 in 10 women and people assigned female at birth of reproductive age β around 1.5 million in the UK.
Suspect endometriosis in anyone, including young people aged 17 and under, with one or more of:
β’ Chronic pelvic pain: pelvic pain for 6 months or longer
β’ Period-related pain (dysmenorrhoea) affecting daily activities and quality of life
β’ Deep pain during or after sex (dyspareunia)
β’ Cyclical or period-related bowel symptoms, especially painful bowel movements (dyschezia)
β’ Cyclical or period-related urinary symptoms, especially blood in the urine or pain passing urine
β’ Infertility in association with any of the above
Symptoms may be cyclical at first but can become constant. Fatigue and a significant psychological and social impact are common.
Ask about a first-degree family history of endometriosis, which increases the likelihood.
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π Key principle β think of it early, believe the symptoms β’ The defining clinical problem is delayed diagnosis: the average woman waits years β often cited as around 8 years β from first symptom to diagnosis. β’ In general practice, think of it early, validate the symptoms, and start managing them rather than waiting for a "definitive" test. β’ A normal examination and a normal ultrasound do not exclude endometriosis. β’ A working ("suspected") diagnosis is valid, and symptoms should be treated while investigation and referral proceed in parallel. |
| Also consider (differential or coexisting) | Discriminating features |
|---|---|
| Adenomyosis | β’ Bulky, tender uterus β’ Heavy and painful periods β’ Often older or parous β’ Frequently coexists with endometriosis |
| Pelvic inflammatory disease | β’ Deep dyspareunia with abnormal discharge, cervical motion tenderness, STI risk factors β’ May be febrile |
| Irritable bowel syndrome | β’ Bloating and altered bowel habit related to defaecation β’ Symptoms not confined to menstruation β’ Often coexists |
| Bladder pain syndrome or interstitial cystitis | Bladder pain with urinary urgency and frequency but sterile urine (no infection). |
| Ovarian cyst (incl. endometrioma) | β’ Adnexal mass β’ Consider acute torsion or rupture if pain is sudden and severe |
| Primary dysmenorrhoea | Pain from menarche, no other features and a normal examination. |
| Pelvic floor or musculoskeletal pain | β’ Localised, often non-cyclical and positional tenderness β’ Reproduced on palpation of the pelvic floor |
Source: NICE NG73
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